Publication:
Murine gammaherpesvirus 68 encodes a second PML-modifying protein

Issued Date

2014-01-01

Resource Type

Article

ISSN

10985514
0022538X

DOI

10.1128/JVI.03081-13

Other identifier(s)

2-s2.0-84894545833

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Virology. Vol.88, No.6 (2014), 3591-3597

Suggested Citation

Jaturong Sewatanon, Paul D. Ling Murine gammaherpesvirus 68 encodes a second PML-modifying protein. Journal of Virology. Vol.88, No.6 (2014), 3591-3597. doi:10.1128/JVI.03081-13 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34023

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Title

Murine gammaherpesvirus 68 encodes a second PML-modifying protein

Author(s)

Jaturong Sewatanon
 Paul D. Ling

Other Contributor(s)

Baylor College of Medicine
 Mahidol University

Abstract

The ORF75c tegument protein of murine gammaherpesvirus 68 (MHV68) promotes the degradation of the antiviral promyelocytic leukemia (PML) protein. Surprisingly, MHV68 expressing a degradation-deficient ORF75c replicated in cell culture and in mice similar to the wild-type virus. However, in cells infected with this mutant virus, PML formed novel track-like structures that are induced by ORF61, the viral ribonucleotide reductase large subunit. These findings may explain why ORF75c mutant viruses unable to degrade PML had no demonstrable phenotype after infection. © 2014, American Society for Microbiology.

Keyword(s)

Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/34023

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