Publication: Hypoglycemic effect of water extract of the root of Pandanus odorus RIDL
Issued Date
1996-01-01
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09186158
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2-s2.0-0029870227
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Mahidol University
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SCOPUS
Bibliographic Citation
Biological and Pharmaceutical Bulletin. Vol.19, No.3 (1996), 364-366
Suggested Citation
Penchom Peungvicha, Suwan S. Thirawarapan, Hiroshi Watanabe Hypoglycemic effect of water extract of the root of Pandanus odorus RIDL. Biological and Pharmaceutical Bulletin. Vol.19, No.3 (1996), 364-366. doi:10.1248/bpb.19.364 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17836
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Title
Hypoglycemic effect of water extract of the root of Pandanus odorus RIDL
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Abstract
Hypoglycemic effect of water extract of the root of Pandanus odorus RIDL. (Thai name: Toei-hom, Pandanaceae) was examined in normal and streptozotocin-diabetic rats. In the hypoglycemic test without glucose load, an administration of the extract at doses of 0.125-0.5 g/kg p.o. did not affect significantly the plasma glucose level in normal rats, whereas the extract significantly lowered the plasma glucose level at a dose of 0.5 g/kg p.o in diabetic rats. In oral glucose tolerance test, an administration of the extract at a dose of 0.5 g/kg p.o. significantly lowered the plasma glucose level in normal rats. The extract at doses of 0.5 and 1.0 g/kg p.o. also significantly lowered the plasma glucose level in diabetic rats. A reference drug, glibenclamide at a dose of 5 mg/kg p.o. showed a significant hypoglycemic effect in both normal and diabetic rats. Repeated administration of the extract at doses of 0.25 and 0.5 g/kg p.o. for 7d produced a significant hypoglycemic effect in diabetic rats. Glibenclamide (5 mg/kg p.o.) also caused a significant hypoglycemia in the diabetic rats. LD50(95% confidence limit) after intraperitoneal injection was 1.87 (1.26-2.76) g/kg in male and female rats and 1.62 (1.18-2.24) g/kg in male and female mice, respectively. The LD50after oral administration was over 8 g/kg in both sexes of rat and mice.