Publication:
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

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dc.contributor.authorChiea Chuen Khoren_US
dc.contributor.authorTan Doen_US
dc.contributor.authorHongyan Jiaen_US
dc.contributor.authorMasakazu Nakanoen_US
dc.contributor.authorRonnie Georgeen_US
dc.contributor.authorKhaled Abu-Ameroen_US
dc.contributor.authorRoopam Duveshen_US
dc.contributor.authorLi Jia Chenen_US
dc.contributor.authorZheng Lien_US
dc.contributor.authorMonisha E. Nongpiuren_US
dc.contributor.authorShamira A. Pereraen_US
dc.contributor.authorChunyan Qiaoen_US
dc.contributor.authorHon Tym Wongen_US
dc.contributor.authorHiroshi Sakaien_US
dc.contributor.authorMônica Barbosa De Meloen_US
dc.contributor.authorMei Chin Leeen_US
dc.contributor.authorAnita SChanen_US
dc.contributor.authorYaakub Azhanyen_US
dc.contributor.authorThi Lam Huong Daoen_US
dc.contributor.authorYoko Ikedaen_US
dc.contributor.authorRodolfo A. Perez-Grossmannen_US
dc.contributor.authorTomasz Zarnowskien_US
dc.contributor.authorAlexander C. Dayen_US
dc.contributor.authorJost B. Jonasen_US
dc.contributor.authorPancy O.S. Tamen_US
dc.contributor.authorTuan Anh Tranen_US
dc.contributor.authorHumaira Ayuben_US
dc.contributor.authorFarah Akhtaren_US
dc.contributor.authorShazia Michealen_US
dc.contributor.authorPaul T.K. Chewen_US
dc.contributor.authorLeyla A. Aljasimen_US
dc.contributor.authorTanuj Dadaen_US
dc.contributor.authorTam Thi Luuen_US
dc.contributor.authorMona S. Awadallaen_US
dc.contributor.authorNaris Kitnarongen_US
dc.contributor.authorBoonsong Wanichwecharungruangen_US
dc.contributor.authorYee Yee Aungen_US
dc.contributor.authorJelinar Mohamed-Nooren_US
dc.contributor.authorSaravanan Vijayanen_US
dc.contributor.authorSripriya Sarangapanien_US
dc.contributor.authorRahat Husainen_US
dc.contributor.authorAliza Japen_US
dc.contributor.authorMani Baskaranen_US
dc.contributor.authorDavid Gohen_US
dc.contributor.authorDaniel H. Suen_US
dc.contributor.authorHuaizhou Wangen_US
dc.contributor.authorVernon K. Yongen_US
dc.contributor.authorLeonard W. Yipen_US
dc.contributor.authorTuyet Bach Trinhen_US
dc.contributor.authorManchima Makornwattanaen_US
dc.contributor.authorThanh Thu Nguyenen_US
dc.contributor.authorEdgar U. Leuenbergeren_US
dc.contributor.authorKi Ho Parken_US
dc.contributor.authorWidya Artini Wiyogoen_US
dc.contributor.authorRajesh SKumaren_US
dc.contributor.authorCelso Telloen_US
dc.contributor.authorYasuo Kurimotoen_US
dc.contributor.authorSuman S. Thapaen_US
dc.contributor.authorKessara Pathanapitoonen_US
dc.contributor.authorJohn F. Salmonen_US
dc.contributor.authorYong Ho Sohnen_US
dc.contributor.authorAntonio Feaen_US
dc.contributor.authorMineo Ozakien_US
dc.contributor.authorJimmy S.M. Laien_US
dc.contributor.authorVisanee Tantisevien_US
dc.contributor.authorChaw Chaw Khaingen_US
dc.contributor.authorTakanori Mizoguchien_US
dc.contributor.authorSatoko Nakanoen_US
dc.contributor.authorChan Yun Kimen_US
dc.contributor.authorGuangxian Tangen_US
dc.contributor.authorSujie Fanen_US
dc.contributor.authorRenyi Wuen_US
dc.contributor.authorHailin Mengen_US
dc.contributor.authorThi Thuy Giang Nguyenen_US
dc.contributor.authorTien Dat Tranen_US
dc.contributor.authorMorio Uenoen_US
dc.contributor.authorJose Maria Martinezen_US
dc.contributor.authorNorlina Ramlien_US
dc.contributor.authorYin Mon Aungen_US
dc.contributor.authorRigo Daniel Reyesen_US
dc.contributor.authorStephen A. Vernonen_US
dc.contributor.authorSeng Kheong Fangen_US
dc.contributor.authorZhicheng Xieen_US
dc.contributor.authorXiao Yin Chenen_US
dc.contributor.authorJia Nee Fooen_US
dc.contributor.otherA-Star, Genome Institute of Singaporeen_US
dc.contributor.otherDuke-NUS Medical School Singaporeen_US
dc.contributor.otherNational University of Singaporeen_US
dc.contributor.otherVietnam National Institute of Ophthalmologyen_US
dc.contributor.otherBeijing Tongren Hospitalen_US
dc.contributor.otherKyoto Prefectural University of Medicineen_US
dc.contributor.otherMedical Research Foundation, Chennaien_US
dc.contributor.otherKing Saud University Medical Collegeen_US
dc.contributor.otherUniversity of Floridaen_US
dc.contributor.otherAravind Medical Research Foundationen_US
dc.contributor.otherChinese University of Hong Kongen_US
dc.contributor.otherTan Tock Seng Hospitalen_US
dc.contributor.otherUniversity of the Ryukyusen_US
dc.contributor.otherUniversidade Estadual de Campinasen_US
dc.contributor.otherSchool of Medical Sciences - Universiti Sains Malaysiaen_US
dc.contributor.otherInstituto de Glaucoma y Catarataen_US
dc.contributor.otherMedical University of Lublinen_US
dc.contributor.otherMoorfields Eye Hospital NHS Foundation Trusten_US
dc.contributor.otherUCL Institute of Ophthalmologyen_US
dc.contributor.otherUniversität Heidelbergen_US
dc.contributor.otherHo Chi Minh City Oncology Hospitalen_US
dc.contributor.otherCOMSATS Institute of Information Technologyen_US
dc.contributor.otherAl-Shifa Trust Eye Hospitalen_US
dc.contributor.otherRadboud University Nijmegen Medical Centreen_US
dc.contributor.otherNational University Health Systemen_US
dc.contributor.otherKing Khaled Eye Specialist Hospitalen_US
dc.contributor.otherAll India Institute of Medical Sciences, New Delhien_US
dc.contributor.otherDa Nang Eye Hospitalen_US
dc.contributor.otherFlinders Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherRajavithi Hospitalen_US
dc.contributor.otherRangsit Universityen_US
dc.contributor.otherUniversity of Medicine-Mandalayen_US
dc.contributor.otherKuala Lumpur Hospitalen_US
dc.contributor.otherVision Research Foundation Indiaen_US
dc.contributor.otherChangi General Hospitalen_US
dc.contributor.otherFaculty of Medicine, Thammasat Universityen_US
dc.contributor.otherViet Tiep General Hospitalen_US
dc.contributor.otherAsian Eye Instituteen_US
dc.contributor.otherUniversity of the East, Philippinesen_US
dc.contributor.otherSeoul National Universityen_US
dc.contributor.otherJakarta Eye Centeren_US
dc.contributor.otherUniversitas Indonesiaen_US
dc.contributor.otherNarayana Nethralaya Eye Hospitalen_US
dc.contributor.otherNew York Eye and Ear Infirmaryen_US
dc.contributor.otherKobe City Medical Center General Hospitalen_US
dc.contributor.otherTilganga Institute of Ophthalmologyen_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherKonyang Universityen_US
dc.contributor.otherUniversità degli Studi di Torinoen_US
dc.contributor.otherOzaki Eye Hospitalen_US
dc.contributor.otherUniversity of Miyazakien_US
dc.contributor.otherThe University of Hong Kongen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherNo. 1 Defence Services General Hospitalen_US
dc.contributor.otherMizoguchi Eye Clinicen_US
dc.contributor.otherOita Universityen_US
dc.contributor.otherYonsei Universityen_US
dc.contributor.otherShijiazhuang First Eye Hospitalen_US
dc.contributor.otherHandan Eye Hospitalen_US
dc.contributor.otherXiamen Universityen_US
dc.contributor.otherAnyang Eye Hospitalen_US
dc.contributor.otherPasig City General Hospitalen_US
dc.contributor.otherUniversity of Malayaen_US
dc.contributor.otherPun Hlaing Silom Hospitalen_US
dc.contributor.otherShwe La Min Hospitalen_US
dc.contributor.otherAsian Hospital and Medical Center, Muntinlupaen_US
dc.contributor.otherBinan Doctors Hospitalen_US
dc.contributor.otherNottingham University Hospitals NHS Trusten_US
dc.contributor.otherBMI Park Hospitalen_US
dc.contributor.otherInternational Specialist Eye Centreen_US
dc.contributor.otherAravind Eye Hospitalen_US
dc.date.accessioned2018-12-11T02:16:22Z
dc.date.accessioned2019-03-14T08:04:04Z
dc.date.available2018-12-11T02:16:22Z
dc.date.available2019-03-14T08:04:04Z
dc.date.issued2016-05-01en_US
dc.description.abstract© 2016 Nature America, Inc. Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10 -5), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10 -6), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10 -4), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10 -1), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10 -2). We also confirmed significant association at three previously described loci (P < 5 × 10 â'8 for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.en_US
dc.identifier.citationNature Genetics. Vol.48, No.5 (2016), 556-562en_US
dc.identifier.doi10.1038/ng.3540en_US
dc.identifier.issn15461718en_US
dc.identifier.issn10614036en_US
dc.identifier.other2-s2.0-84963502585en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/43017
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84963502585&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleGenome-wide association study identifies five new susceptibility loci for primary angle closure glaucomaen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84963502585&origin=inwarden_US

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