Publication: Factors predicting pathologic significance among women with atypical glandular cells on liquid-based cytology
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Issued Date
2012-01-01
Resource Type
ISSN
18793479
00207292
00207292
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2-s2.0-84865991319
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Gynecology and Obstetrics. Vol.119, No.1 (2012), 30-34
Suggested Citation
Usanee Chatchotikawong, Irene Ruengkhachorn, Somsak Laiwejpithaya Factors predicting pathologic significance among women with atypical glandular cells on liquid-based cytology. International Journal of Gynecology and Obstetrics. Vol.119, No.1 (2012), 30-34. doi:10.1016/j.ijgo.2012.05.027 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15064
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Title
Factors predicting pathologic significance among women with atypical glandular cells on liquid-based cytology
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Abstract
Objective: To determine incidence, originating organ, and factors predicting significant histopathology (premalignant and malignant lesions) among women with atypical glandular cells (AGCs) on liquid-based cytology (LBC). Methods: In a retrospective study at Siriraj Hospital, Bangkok, Thailand, clinical and histologic data were reviewed for women with AGCs who underwent appropriate examinations from January 2007 to December 2010. Results: There were 284 women with AGC cytology (mean age, 51.2 years). The incidence of significant pathology and invasive cancer was 43.3% and 34.5%, respectively. The most common malignant organ was the uterus (64/123, 52%). Predictors of serious pathology were AGC favor neoplasia (AGC-FN) endocervical (odds ratio [OR], 5.64; 95% confidence interval [CI] , 1.62-19.57), AGC-FN endometrial (OR, 4.11; 95% CI, 1.27-13.32), AGC-FN glandular (OR, 8.23; 95% CI, 2.02-33.49) subtypes, and bleeding (OR, 2.88; 95% CI, 1.47-5.65). Combining patient age and AGC subtype, there were no serious cervical lesions among women aged 50 years or younger with AGC-FN glandular subtype, or serious non-cervical neoplasia among women aged 50 years or younger with AGC not otherwise specified (AGC-NOS) or AGC-FN endocervical subtypes. Conclusion: AGC subcategories defined from LBC, alone or combined with patient age, might be predictors of significant histopathology, cancer incidence, and originating organ. © 2012 International Federation of Gynecology and Obstetrics.