Publication: Complex interactions of δβ hybrid haemoglobin (Hb Lepore-Hollandia) Hb E (β<sup>26 g→a</sup>) and α<sup>+</sup>thalassaemia in a Thai family
14
Issued Date
2002-05-18
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ISSN
09024441
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2-s2.0-0035983105
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Haematology. Vol.68, No.2 (2002), 107-111
Suggested Citation
Vip Viprakasit, Parichat Pung-Amritt, Lerlugh Suwanthon, Kevin Clark, Voravarn S. Tanphaichitr Complex interactions of δβ hybrid haemoglobin (Hb Lepore-Hollandia) Hb E (β<sup>26 g→a</sup>) and α<sup>+</sup>thalassaemia in a Thai family. European Journal of Haematology. Vol.68, No.2 (2002), 107-111. doi:10.1034/j.1600-0609.2002.01637.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20489
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Title
Complex interactions of δβ hybrid haemoglobin (Hb Lepore-Hollandia) Hb E (β<sup>26 g→a</sup>) and α<sup>+</sup>thalassaemia in a Thai family
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Abstract
Haemoglobin Lepore-Hollandia is an extremely rare condition in which a small deletion gives rise to a δβ hybrid, β-like globin. There are two single reports of patients from South Pacific Islands and Bangladesh. We describe a family from central Thailand, in which this Hb Lepore-Hollandia interacts with a common β globin variant (βEresulting from the codon 26, G→A mutation) and α+thalassaemia (-α3.7). This intriguing interaction caused a troublesome diagnosis, as the two proband brothers were diagnosed as having Hb E/β thalassaemia. Molecular analysis of genomic DNA performed in this study allowed the definitive diagnosis of this complicated interaction. Such studies are required in the diagnosis of thalassaemia and haemoglobinopathies for particular regions like South-east Asia, where many different genotypes may give rise to haemoglobin disorders.