Publication: 6 HCV Genotyping 9G test for HCV 1a, 1b, 2, 3, 4 and 6 (6a, 6f, 6i and 6n) with high accuracy
Issued Date
2017-08-01
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ISSN
18790984
01660934
01660934
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2-s2.0-85018759094
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Virological Methods. Vol.246, (2017), 95-99
Suggested Citation
Wasun Chantratita, Keum Soo Song, Satish Balasaheb Nimse, Viroj Pongthanapisith, Nipa Thongbaiphet, Garanyuta Wongtabtim, Ekawat Pasomsub, Kanokwan Angkanavin, Mukesh Digambar Sonawane, Shrikant Dasharath Warkad, Taisun Kim 6 HCV Genotyping 9G test for HCV 1a, 1b, 2, 3, 4 and 6 (6a, 6f, 6i and 6n) with high accuracy. Journal of Virological Methods. Vol.246, (2017), 95-99. doi:10.1016/j.jviromet.2017.04.017 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/42775
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Title
6 HCV Genotyping 9G test for HCV 1a, 1b, 2, 3, 4 and 6 (6a, 6f, 6i and 6n) with high accuracy
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Abstract
© 2017 Elsevier B.V. According to EASL guidelines and WHO recommendations, the accurate detection of HCV genotypes such as HCV 1a, HCV1b, HCV 2, HCV 3, HCV 4, and HCV 6 (6a, 6f, 6i, 6n) is crucial for the efficient treatment of hepatitis C. HCV Genotyping 9G test allows simultaneous genotyping of HCV 1a, 1b, 2, 3, 4, and 6 (6a, 6f, 6i, and 6n) in clinical samples in 30 min. The performance of the test was evaluated by comparison with sequence analysis. Serum samples (n = 152) from HCV-infected patients (n = 110) and healthy individuals (n = 42) were processed under blinded codes. The k coefficient (kappa) values indicated high agreement between the HCV Genotyping 9G test and sequencing. The sensitivity and specificity of the test were 99.1% and 99.7%, respectively. The results indicate that HCV Genotyping 9G test is rapid, reliable, sensitive, and accurate for screening and genotyping of HCV in the clinical specimens.