Publication:
Evaluation of ethyl: N -(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

Issued Date

2016-01-01

Resource Type

Article

ISSN

14770520

DOI

10.1039/c6ob00706f

Other identifier(s)

2-s2.0-84978785857

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Organic and Biomolecular Chemistry. Vol.14, No.28 (2016), 6853-6856

Suggested Citation

Matthew D. Stephens, Nisakorn Yodsanit, Christian Melander Evaluation of ethyl: N -(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus. Organic and Biomolecular Chemistry. Vol.14, No.28 (2016), 6853-6856. doi:10.1039/c6ob00706f Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43198

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Title

Evaluation of ethyl: N -(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

Author(s)

Matthew D. Stephens
 Nisakorn Yodsanit
 Christian Melander

Other Contributor(s)

North Carolina State University
 Mahidol University

Abstract

© 2016 The Royal Society of Chemistry. A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N-(2-phenethyl) carbamate. Screening of the compounds revealed a potent analogue capabale of inhibiting several strains of Methicillin Resistant S. aureus biofilms with low to moderate micromolar IC50values.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/43198

Collections

Scopus 2016-2017