Publication: Comparative study of fluconazole and clotrimazole for the treatment of vulvovaginal candidiasis
Issued Date
1995-01-01
Resource Type
ISSN
15374521
01485717
01485717
Other identifier(s)
2-s2.0-0029124991
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Mahidol University
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SCOPUS
Bibliographic Citation
Sexually Transmitted Diseases. Vol.22, No.4 (1995), 228-230
Suggested Citation
Pratak O-Prasertsawat, Athicom Bourlert Comparative study of fluconazole and clotrimazole for the treatment of vulvovaginal candidiasis. Sexually Transmitted Diseases. Vol.22, No.4 (1995), 228-230. doi:10.1097/00007435-199507000-00005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17469
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Title
Comparative study of fluconazole and clotrimazole for the treatment of vulvovaginal candidiasis
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Abstract
Background: The introduction of the triazole antifungal agent fluconazole, which can be used via an oral route and single dose, has had a significant impact on patient compliance. Goal of this Study: To compare the efficacy and safety of a single oral dose of 150 mg fluconazole with that of a 100-mg clotrimazole vaginal suppository twice a day in the morning and at bedtime for 3 days in the treatment of vulvovaginal candidiasis. Study Design: A single-blind, randomized controlled trial was conducted at Ramathibodi Hospital between June 1 and September 30, 1993. Results: There were 53 women in the group treated with fluconazole and 50 in the group treated with clotrimazole. There was no significant difference between the two groups regarding clinical characteristics (age and length of follow-up period). My- cological cure rates approximately 1 week after treatment were 79.2% in the fluconazole group and 80.0% in the clotrimazole group. Approximately 4 weeks after treatment, these rates were 60.4% and 66.0%, respectively. The side effects were minimal and did not warrant any treatment. The differences in the results were not statistically significant. Conclusion: We recommend that a single oral dose of 150 mg of fluconazole be given as an alternative method of treating vulvovaginal candidiasis, but the cost is higher than for clotrimazole. © 1995 American Sexually Transmitted Diseases Association.