Publication: The aging gut motility decay: May symbiotics be acting as "implantable" biologic pace-makers?
Issued Date
2006-06-01
Resource Type
ISSN
15491684
Other identifier(s)
2-s2.0-33744948334
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Mahidol University
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SCOPUS
Bibliographic Citation
Rejuvenation Research. Vol.9, No.2 (2006), 342-345
Suggested Citation
Y. Metugriachuk, F. Marotta, K. Pavasuthipaisit, O. Kuroi, J. Tsuchiya, A. Lorenzetti, E. Fesce, E. Minelli The aging gut motility decay: May symbiotics be acting as "implantable" biologic pace-makers?. Rejuvenation Research. Vol.9, No.2 (2006), 342-345. doi:10.1089/rej.2006.9.342 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23035
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Title
The aging gut motility decay: May symbiotics be acting as "implantable" biologic pace-makers?
Abstract
Motility recording of small and large intestine was performed in old Wistar rats divided into three groups: (a) standard diet, (b) standard diet plus a symbiotic preparation, and (c) standard diet plus a heat-inactivated symbiotic preparation. SCM-III. significantly increased the myoelectric activity of small intestine and colon (p < 0.01 versus [a] and [c]) paralleling "young" values of 4-month-old rats and increased the spike burst frequency in the proximal-distal colon (p < 0.05). SCM-III significantly increased the frequency and duration of spike bursts in the jejunum, transverse-distal colon, and defecation frequency, while decreasing the intervals of migrating motor complex in the colon (p < 0.01) to "young" values with an increased mRNA expression of VIP (p < 0.05). Gut flora manipulation aimed to modulate myoelectric activity can tentatively help reversing age-related motility decay. © Mary Ann Liebert, Inc.
