Biochemical markers of bone turnover in angiographically-demonstrated coronary artery disease patients and healthy Thais

Abstract

The patients with coronary artery disease (CAD) were suffering from dyspnea. Physical activity of these patients was limited. Their lifestyle may be contributory factors for osteoporosis. Recent research has shown that biochemical markers may be used to predict future bone loss and identify individuals at risk for osteoporosis. Our objectives were to estimate reference ranges of bone markers in healthy Thais and to compare bone turnover between 105 healthy people and 118 CAD patients by using biochemical markers of bone formation and resorption. Mean values of bone markers in controls and patients were 22.9 ± 12.9, 21.6 ± 16.2 respectively for N-Mid osteocalcin and 0.45 ± 0.30, 0.47 ± 0.37 respectively for β-Crosslaps. There was no statistical difference of N-Mid osteocalcin (p=0.50) and β-Crosslaps (p=0.64) values between groups. Our data from this study suggested that that CAD patients have no higher risk for osteoporosis than healthy people.