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Cutaneous Adverse Drug Reactions in the Elderly: a Retrospective Analysis in Thailand

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dc.contributor.authorPapapit Tuchindaen_US
dc.contributor.authorLeena Chularojanamontrien_US
dc.contributor.authorThanisorn Sukakulen_US
dc.contributor.authorKanchalit Thanomkittien_US
dc.contributor.authorSunatra Nitayavardhanaen_US
dc.contributor.authorKowit Jongjarearnpraserten_US
dc.contributor.authorPanadda Uthaitasen_US
dc.contributor.authorKanokvalai Kulthananen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-11-09T02:45:52Z
dc.date.available2018-11-09T02:45:52Z
dc.date.issued2014-01-01en_US
dc.description.abstract© 2014, Springer International Publishing Switzerland. Background: Elderly people tend to be sicker than young people. They also take more medications, increasing the risk of adverse drug reactions (ADRs), which are one of the leading causes of morbidity and mortality in this age group. Knowledge of cutaneous ADRs from medicine use in the elderly population is limited.Objective: The aim of this study was to investigate demographic data, causative drugs and cutaneous manifestations of ADRs in elderly patients.Methods: A retrospective analysis was conducted involving elderly patients aged >60 years with cutaneous ADRs in the period from 2002 to 2012. We analyzed data with respect to demographic data, clinical data, outcomes, and risk factors for serious reactions.Results: A total of 400 patient records were included. The mean age was 73.6 years, and 53 % were women. The common reactions were maculopapular rash (65 %) and angioedema with/without urticaria (11.3 %). Antibiotics (42.8 %) and non-steroidal anti-inflammatory drugs (9.5 %) were common causative drugs. Serious cutaneous ADRs were found in 16.5 %.Conclusion: Our results show that multiple underlying medical conditions, especially cerebrovascular diseases, are risk factors for serious cutaneous ADRs in elderly patients. These findings emphasize the need for awareness about cutaneous drug reactions in elderly patients.en_US
dc.identifier.citationDrugs and Aging. Vol.31, No.11 (2014), 815-824en_US
dc.identifier.doi10.1007/s40266-014-0209-xen_US
dc.identifier.issn11791969en_US
dc.identifier.issn1170229Xen_US
dc.identifier.other2-s2.0-84919928615en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14594/34425
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84919928615&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleCutaneous Adverse Drug Reactions in the Elderly: a Retrospective Analysis in Thailanden_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84919928615&origin=inwarden_US
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