Publication: Inhibition of mitochondrial ATPase by 2,4,3′,5′-tetrahydroxystilbene
Issued Date
1977-01-01
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ISSN
00092797
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2-s2.0-0017685999
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Mahidol University
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SCOPUS
Bibliographic Citation
Chemico-Biological Interactions. Vol.18, No.3 (1977), 355-364
Suggested Citation
Withaya Janthasoot, Kavi Ratanabanangkoon, Prakorn Chudapongse Inhibition of mitochondrial ATPase by 2,4,3′,5′-tetrahydroxystilbene. Chemico-Biological Interactions. Vol.18, No.3 (1977), 355-364. doi:10.1016/0009-2797(77)90021-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/10334
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Title
Inhibition of mitochondrial ATPase by 2,4,3′,5′-tetrahydroxystilbene
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Abstract
2,4,3′,5′-tetrahydroxystilbene (THS) was found to inhibit rat liver mitochondrial adenosine triphosphatase (ATPase) activity induced by various concentrations of 2,4-dinitrophenol (DNP). The I 50 was found to be 17 nmoles/mg mitochondrial protein. The maximum inhibitory effects of oligomycin and atractyloside on the DNP-activated mitochondrial ATPase activity can be enhanced by adding THS. The atractyloside-insensitive ATPase activity of Lubrol-treated rat liver mitochondria was also inhibited by low concentration of THS. The tetramethoxy derivative of THS was much less effective than the parent compound in depressing the ATPase activity of both intact and Lubrol-treated mitochondria. These observations suggest that the phenolic groups are essential for the mitochondrial actions of THS, and this compound most probably acts by a mechanism different from oligomycin on the mitochondrial ATPase complex. © 1977.