Publication: Association between Vitamin D and uric acid in adults: A systematic review and meta-analysis
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Issued Date
2020-10-01
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ISSN
14394286
00185043
00185043
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2-s2.0-85092885566
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Mahidol University
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SCOPUS
Bibliographic Citation
Hormone and Metabolic Research. Vol.52, No.10 (2020), 732-741
Suggested Citation
Ronny Isnuwardana, Sanjeev Bijukchhe, Kunlawat Thadanipon, Atiporn Ingsathit, Ammarin Thakkinstian Association between Vitamin D and uric acid in adults: A systematic review and meta-analysis. Hormone and Metabolic Research. Vol.52, No.10 (2020), 732-741. doi:10.1055/a-1240-5850 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/59874
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Title
Association between Vitamin D and uric acid in adults: A systematic review and meta-analysis
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Abstract
© 2020. The Author(s). Association between vitamin D and uric acid is complex and might be bidirectional. Our study aimed to determine the bidirectional association between vitamin D and uric acid in adults. Using MEDLINE via PubMed and Scopus, we systematically searched for observational or interventional studies in adults, which assessed the association between serum vitamin D and serum uric acid, extracted the data, and conducted analysis by direct and network meta-analysis. The present review included 32 studies, of which 21 had vitamin D as outcome and 11 had uric acid as outcome. Meta-analysis showed a significant pooled beta coefficient of serum uric acid level on serum 25(OH)D level from 3 studies of 0.512 (95 % confidence interval: 0.199, 0.825) and a significant pooled odds ratio between vitamin D deficiency and hyperuricemia of 1.496 (1.141, 1.963). The pooled mean difference of serum 25(OH)D between groups with hyperuricemia and normouricemia was non-significant at 0.138 (− 0.430, 0.707) ng/ml, and the pooled mean difference of serum uric acid between categories of 25(OH)D were also non-significant at 0.072 (− 0.153, 0.298) mg/dl between deficiency and normal, 0.038 (− 0.216, 0.292) mg/dl between insufficiency and normal, and 0.034 (− 0.216, 0.283) mg/dl between deficiency and insufficiency. In conclusion, increasing serum uric acid might be associated with increasing 25(OH)D level, while vitamin D deficiency is associated with hyperuricemia. These reverse relationships should be further evaluated in a longitudinal study.