Study of normal values in coagulation profile

Abstract

The objective of the present work was to study normal values of hemostasis parameters in healthy volunteers using Behring Coagulation Timer (BCT). Plasma was divided into 2 parts fresh plasma and lyophilized plasma. It was found that the mean ± SD of prothrombin time (PT) and activated partial thromboplastin time (APTT) in fresh plasma (n=37) were 11.95 ± 0.7 and 40.52 ± 5.30 seconds respectively. The means ± SD of coagulation factors I, II, VII, VIII and IX were 2.55 ± 0.73 g/l (n=36), 82.28 ± 10.28 per cent (n=37), 82.79 ± 19.36 per cent (n=32), 89.13 ± 24.17 per cent (n=37), 94.11 ± 16.29 per cent (n=31) respectively. The normal ranges (P5-P95) of PT, APTT and coagulation factors I, II, VII, VIII and IX were 10.8-13.3 sec, 31.4-48.0 sec and 1.82-4.65 g/l, 64.83-96.5 per cent, 46.88-113.5 per cent, 52.44-127.61 per cent and 67.87-116.94 per cent respectively. Comparison of PT, APTT between fresh plasma and lyophilized plasma were statistically different (Wilcoxon match-pair signed rank test, p<0.05), while F I, II, VIII and F.IX in fresh plasma were increased more significantly than lyophilized plasma.