Publication: Severe nonfebrile dengue infection in an adolescent after postoperative kidney transplantation: A case report
Issued Date
2012-01-01
Resource Type
ISSN
18732623
00411345
00411345
Other identifier(s)
2-s2.0-84858725543
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Mahidol University
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SCOPUS
Bibliographic Citation
Transplantation Proceedings. Vol.44, No.1 (2012), 303-306
Suggested Citation
K. Tangnararatchakit, W. Tirapanich, W. Tapaneya-Olarn, V. Sumethkul, N. Sirachainan, S. Watcharananan, C. Leenanupunth, S. Yoksan, A. Chuansumrit Severe nonfebrile dengue infection in an adolescent after postoperative kidney transplantation: A case report. Transplantation Proceedings. Vol.44, No.1 (2012), 303-306. doi:10.1016/j.transproceed.2011.11.025 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15061
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Title
Severe nonfebrile dengue infection in an adolescent after postoperative kidney transplantation: A case report
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Abstract
We herein have reported a case of severe nonfebrile dengue infection complicated with refractory pancytopenia and a large perinephric hematoma with shock in a 16-year-old adolescent during the early postoperative period after kidney transplantation. After the diagnosis of end-stage renal disease she underwent living-related kidney transplantation. Thirteen days after successful transplantation, she exhibited a notable amount of ascites, bilateral pleural effusions, thrombocytopenia, and increased hemoglobin without pre-existent fever. Further investigation revealed positive dengue nonstructural protein 1 antigen (dengue NS1 Ag) and dengue virus serotype 1 by a reverse transcriptase-polymerase chain reaction (RT-PCR) in the patient's serum. She exhibited hemophagocytic syndrome, manifested by refractory pancytopenia and refractory anemia resulting in hypovolemic shock and acute graft failure on day 28 posttransplantation. The anemia was attributed to a large hematoma around the transplanted kidney requiring surgical evacuation of clotted blood. Postoperatively, she gradually recovered with resolution of thrombocytopenia and excellent graft function. Persistent dengue antigenemia and viremia was shown by dengue NS1 Ag and RT-PCR of dengue serotype-1. The viremia was present longer than the dengue antigenemia. Dengue-specific immunoglobulin M (IgM) and IgG by enzyme-linked immunosorbent assay confirmed the primary dengue infection and evidence of a recent donor dengue infection. © 2012 Published by Elsevier Inc.