Publication: Cut-off values for positive bronchodilator response in healthy Thai preschool children using forced oscillation technique
Issued Date
2020-12-01
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0125877X
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2-s2.0-85098108342
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific journal of allergy and immunology. Vol.38, No.4 (2020), 258-263
Suggested Citation
Kanokporn Udomittipong, Jurairut Triwatanawong, Akarin Nimmannit, Chulaluk Komoltri Cut-off values for positive bronchodilator response in healthy Thai preschool children using forced oscillation technique. Asian Pacific journal of allergy and immunology. Vol.38, No.4 (2020), 258-263. doi:10.12932/AP-280718-0381 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/60936
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Title
Cut-off values for positive bronchodilator response in healthy Thai preschool children using forced oscillation technique
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Abstract
BACKGROUND: Forced oscillation technique (FOT) requires minimal patient cooperation and is particularly useful in young children. Bronchodilator test is a valuable tool for wheezy and asthmatic patients. The cut-off value for bronchodilator response by FOT in healthy Thai children has not been reported. OBJECTIVE: To determine the cut-off values for positive bronchodilator response in healthy Thai preschool children using pseudorandom FOT. METHODS: FOT was used to measure respiratory function at baseline and after 400 mcg MDI salbutamol in healthy Thai children aged 3-6 years. Respiratory resistance (Rrs) and reactance (Xrs) at 6, 8, and 10 Hz were collected. Pre- and post-bronchodilator tests were compared using paired t-test. Absolute and percent changes after bronchodilator were calculated and their cut-off values were defined as mean ± 1.96 SD. Correlation between each of those and baseline data was analyzed using Pearson's correlation coefficient. RESULTS: Of the 150 enrolled children, FOT measurement at baseline and after bronchodilator was successfully completed in 111 children (51 boys). The mean ± standard deviation age, height, and arm span was 5.2 ± 1.1 years, 109.3 ± 8.7 cm, and 107.2 ± 9.1 cm, respectively. No correlation was observed between any absolute or percent changes in bronchodilator response and gender, age, height, or arm span. The cut-off values established for bronchodilator response by percent change were, as follows: Rrs6: -23%, Rrs8: -20%, Rrs10: -20%, Xrs6: 36%, Xrs8: 60%, and Xrs10: 43%. CONCLUSIONS: The cut-off values identified in this study will be useful for evaluating bronchodilator response by FOT in wheezy and asthmatic young children.
