J. Ungwitayatorn, M. Pickert, A. W. Frahm Quantitative structure-activity relationship (QSAR) study of polyhydroxyxanthones. Pharmaceutica Acta Helvetiae. Vol.72, No.1 (1997), 23-29. doi:10.1016/S0031-6865(96)00043-X Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17902
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Quantitative structure-activity relationship (QSAR) study of polyhydroxyxanthones
In the present study13C-chemical shift additivity rules are developed for polyhydroxyxanthones with antituberculotic activity against Mycobacterium tuberculosis. QSAR investigations are performed by correlating13C-chemical shifts and calculated dipole moments of several 1,3-substituted polyhydroxyxanthones with their antituberculotic activity and by using the CoMFA approach as a three-dimensional QSAR method.
