Publication: Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization
Issued Date
2019-08-03
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ISSN
15322335
15257770
15257770
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2-s2.0-85063631756
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Mahidol University
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SCOPUS
Bibliographic Citation
Nucleosides, Nucleotides and Nucleic Acids. Vol.38, No.8 (2019), 578-589
Suggested Citation
Ninticha Thavoncharoensub, Kento Maruyama, Choon Han Heh, Kok Hoong Leong, Hui Shi, Yoshiharu Shigematsu, Shigeki Sasaki, Yosuke Taniguchi Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization. Nucleosides, Nucleotides and Nucleic Acids. Vol.38, No.8 (2019), 578-589. doi:10.1080/15257770.2019.1586919 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50108
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Title
Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization
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Abstract
© 2019, © 2019 Taylor & Francis Group, LLC. 8-OxodGTP is generated by the reaction between dGTP and reactive oxygen species and a considered mutagenic nucleotide. It can be incorporated into the duplex DNA during replication processes by the DNA polymerase, and thus the repair enzyme removes oxodGTP from the nucleotide pools in living cells. On the other hand, the γ-modified triphosphates show interesting properties for use as biological tools. Therefore, the γ-N-pyrenylalkyl-oxodGTP derivatives were synthesized and their effect on the enzymatic reactions were evaluated. The γ-N-pyrenylmethyl-oxodGTP was found to be accepted by the DNA polymerase just like oxodGTP, but showed a competitive inhibition property for the human oxodGTPase.