Publication: Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib
Issued Date
2018-07-18
Resource Type
ISSN
14786427
14786419
14786419
Other identifier(s)
2-s2.0-85032834475
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research. Vol.32, No.14 (2018), 1682-1689
Suggested Citation
Pongpol Thanuphol, Yukihiro Asami, Kazuro Shiomi, Ariyaphong Wongnoppavich, Patoomratana Tuchinda, Noppamas Soonthornchareonnon Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib. Natural Product Research. Vol.32, No.14 (2018), 1682-1689. doi:10.1080/14786419.2017.1396588 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44714
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib
Other Contributor(s)
Abstract
© 2017, 2017 Informa UK Limited, trading as Taylor & Francis Group. The ethanolic extract from the stem bark of Goniothalamus marcanii Craib was shown in preliminary brine shrimp lethality data having good cytotoxic activity. Further bioassay guided isolation was done by means of solvent partition, chromatography and precipitation to provide four isolated compounds: a novel compound 1 with the core structure of 1-azaanthraquinone moiety referred as marcanine G; as well as compounds 2–4 with known aristolactam structures namely, piperolactam C, cepharanone B and taliscanine. These compounds were characterised by spectroscopic techniques. The assessment of cytotoxicity was established on an SRB assay using doxorubicin as a positive control. Marcanine G (1) was considered the most active compound indicating the IC 50 values of 14.87 and 15.18M against human lung cancer cells (A549) and human breast cancer cells (MCF7), respectively. However, 2 showed mild activity with the IC 50 values of 83.72 and 82.32 μM against A549 and MCF7 cells, respectively.