Publication: Evaluation of bioactive glass incorporated poly(caprolactone)-poly(vinyl alcohol) matrix and the effect of BMP-2 modification
Issued Date
2017-05-01
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ISSN
09284931
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2-s2.0-85009961842
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Mahidol University
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SCOPUS
Bibliographic Citation
Materials Science and Engineering C. Vol.74, (2017), 47-54
Suggested Citation
Khamsone Keothongkham, Narattaphol Charoenphandhu, Jirawan Thongbunchoo, Panan Suntornsaratoon, Nateetip Krishnamra, I. Ming Tang, Weeraphat Pon-On Evaluation of bioactive glass incorporated poly(caprolactone)-poly(vinyl alcohol) matrix and the effect of BMP-2 modification. Materials Science and Engineering C. Vol.74, (2017), 47-54. doi:10.1016/j.msec.2016.12.128 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42601
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Title
Evaluation of bioactive glass incorporated poly(caprolactone)-poly(vinyl alcohol) matrix and the effect of BMP-2 modification
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Abstract
© 2017 Composite materials having mechanical and biological properties similar to those of human bones are needed for bone regeneration and repair. In the present study, composites were made by incorporating bioactive glass (BG) into polycaprolactone (PCL)-polyvinyl alcohol (PVA) (PCLPVA) matrix. Composites with different BG contents of 10, 25 and 50 wt% were fabricated by an in-situ blending method. Physicochemical properties measurements found that the composite with 50 wt% BG in the PCLPVA organic matrix exhibited the best mechanical properties (compressive strength and compressive young's modulus up to 32.26 MPa and 530.91 MPa, respectively). We investigated the effects of the BG content on cell adhesion, proliferation and osteogenic activity of UMR-106 cells grown on the scaffolds using in vitro cell culture assay. The composite scaffolds having 25 wt% BG showed a significant increase in their cell adhesion capability and a faster cell proliferation. They also exhibited cell adhesion and spreading morphology after only 5 days of culturing. For these reasons, we chose to attach the bone morphogenetic protein (BMP)-2 to this composite. The resulting composite (labeled BMP-2-loaded PCLPVABG25) showed significant improvement in the UMR-106 cells adhesion, in the enhancement in osteogenic differentiation and osteoinductivity of this composite.