Publication:
Hypothalamic and zona incerta neurons in sheep, initially only responding to the sight of food, also respond to the sight of water after intracerebroventricular injection of hypertonic saline or angiotensin II

Issued Date

2002-01-25

Resource Type

Article

ISSN

00068993

DOI

10.1016/S0006-8993(01)03283-8

Other identifier(s)

2-s2.0-0037169208

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Brain Research. Vol.925, No.2 (2002), 204-212

Suggested Citation

Suriyaphun S. Mungarndee, Basil A. Baldwin, Chittin Chindadoungratana, Naiphinich Kotchabhakdi Hypothalamic and zona incerta neurons in sheep, initially only responding to the sight of food, also respond to the sight of water after intracerebroventricular injection of hypertonic saline or angiotensin II. Brain Research. Vol.925, No.2 (2002), 204-212. doi:10.1016/S0006-8993(01)03283-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20084

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Title

Hypothalamic and zona incerta neurons in sheep, initially only responding to the sight of food, also respond to the sight of water after intracerebroventricular injection of hypertonic saline or angiotensin II

Author(s)

Suriyaphun S. Mungarndee
 Basil A. Baldwin
 Chittin Chindadoungratana
 Naiphinich Kotchabhakdi

Other Contributor(s)

The Institute of Science and Technology for Research and Development, Mahidol University

Abstract

Extracellular single-unit recordings were made from neurons in the lateral hypothalamus (LH) or zona incerta (ZI) of conscious sheep. A small population of neurons (12/83) were found which responded with increased firing rate when the animal looked at food but did not respond when the sheep looked at water. The effects of rapidly inducing intense thirst by the intracerebroventricular (i.c.v.) injection of hypertonic (0.85 M) saline or 200 ng of angiotensin II, or a mixture of the two dipsogenic stimuli, on the response of neurons initially responding only to the sight of food were investigated. Following i.c.v. injection of the dipsogenic stimuli the neurons began to respond strongly to the sight of water. The results demonstrated that changing the animal's motivational state alters the response of some neurons in the LH and ZI and suggests that the neuronal response is influenced by the animal's dominant need at the time of testing. © 2002 Elsevier Science B.V. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Medicine
 Neuroscience

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/20084

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Scopus 2001-2005