Publication: Immunoassays of amphetamines: Immunogen structure vs antibody specificity
Issued Date
1992-12-01
Resource Type
ISSN
0125877X
Other identifier(s)
2-s2.0-0026967532
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.10, No.2 (1992), 159-164
Suggested Citation
P. Suttijitpaisal, K. Ratanabanangkoon Immunoassays of amphetamines: Immunogen structure vs antibody specificity. Asian Pacific Journal of Allergy and Immunology. Vol.10, No.2 (1992), 159-164. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22348
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Title
Immunoassays of amphetamines: Immunogen structure vs antibody specificity
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Abstract
Various immunoassays have been developed for the detection of amphetamines. These have varying degrees of cross-reactivity to other drug and food components. Information on the immunogen structures used, and the specificities of the antibodies obtained, have allowed formulation of a 'structure-specificity' pattern delineated on the basis of immunochemistry and stereochemistry. The 'structure-specificity' relationship should be useful to future developments of these immunoassays. Specifically, immunoassays intended to detect either amphetamine or methamphetamine with minimal cross-reactlon, should employ immunogens with amphetamine (or methamphetamine) derivatized via the para position of the phenyl ring. Such assays should show minimal cross-reaction with other secondary (or tertiary) amines but should strongly cross-react with phenyl ring substituted analogs. On the other hand, assays intended for detection of both amphetamine and methamphetamine should employ amphetamine (rather than methamphetamine) derivatized via its amino group as an immunogen. Such assays should show minimal cross-reaction with other tertiary amines and phenyl-substituted amphetamine/methamphetamine.