Publication: Outcomes of Thai patients with acute ischemic stroke after intravenous thrombolysis
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Issued Date
2011-01-15
Resource Type
ISSN
0022510X
Other identifier(s)
2-s2.0-78650512459
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Neurological Sciences. Vol.300, No.1-2 (2011), 74-77
Suggested Citation
Pornpatr A. Dharmasaroja, Permphan Dharmasaroja, Sombat Muengtaweepongsa Outcomes of Thai patients with acute ischemic stroke after intravenous thrombolysis. Journal of the Neurological Sciences. Vol.300, No.1-2 (2011), 74-77. doi:10.1016/j.jns.2010.09.029 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/12699
Research Projects
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Thesis
Title
Outcomes of Thai patients with acute ischemic stroke after intravenous thrombolysis
Other Contributor(s)
Abstract
The purpose of this study was to assess outcomes in Thai patients after treatment with intravenous recombinant tissue plasminogen activator (rtPA) and to determine the factors associated with good outcome and death. Methods: Patients with acute ischemic stroke who were treated with intravenous rtPA at Thammasat University Hospital between June 2007 and April 2010 were included. The measured outcome variables were good outcome (mRS 0,1) and death at 3 months. Stepwise multivariable analyses were performed by including the prespecified factors that were associated with the measured outcome variables in the univariate analysis. Results: The sample size was 197 patients. At 3 months, 93 patients (47%) had good outcomes while 23 patients (12%) died within the same period. Severe stroke (OR 0.19, 95% CI 0.08-0.44, p-value < 0.0001) and history of hypertension (OR 0.39, 95% CI 0.16-0.93, p-value = 0.033) were independently related to bad outcome at 3 months, while receiving intravenous nicardipine (OR 2.76, 95% CI 1.09-6.94, p-value = 0.032) was associated with good outcome. Severe stroke (OR 5.89, 95% CI 1.29-26.85, p-value = 0.022) and pretreatment high blood glucose levels (OR 8.06, 95% CI 1.21-53.62, p-value = 0.031) each were independently associated with patient death. Conclusions: Standard-dose intravenous rtPA in a cohort of Thai patients led to better clinical outcomes and comparable death rates when compared to other Asian cohorts receiving intravenous rtPA. Several factors were independently associated with patient outcomes at 3 months. © 2010 Elsevier B.V.