Publication: Thyroid function in healthy thai neonates
Issued Date
1999-12-01
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ISSN
01252208
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2-s2.0-28144446512
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.82, No.SUPPL. (1999)
Suggested Citation
Pat Mahachoklertwattana, Arporn Sriphrapradang, Sarayut Supapannachart, Aroonwan Pongsuwan, Lulin Choubtum, Rajata Rajatanavin Thyroid function in healthy thai neonates. Journal of the Medical Association of Thailand. Vol.82, No.SUPPL. (1999). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25540
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Title
Thyroid function in healthy thai neonates
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Abstract
Objectives: To construct a normative data for serum thyroxine (T4), free T4(FT4), triiodothyronine (T3) and thyrotropin (TSH) in Thai neonates. Study design: A cross-sectional study of 275 healthy full-term neonates was conducted. Blood samples were obtained from umbilical cords of the neonates and from heel pads of infants aged 1-30 days. Hormone measurements included serum T4, FT4, T3and TSH. Results: Mean serum T4and FT4levels rapidly increased after delivery to the maximum level at 1-3 days of age. Thereafter, they declined to a steady state level within 2-4 weeks. Mean serum T3level was very low at birth. The concentration increased 3-5 times and reached a steady state levels within 1 week. In contrast, mean serum TSH declined from birth and the level at 1-3 days of age was slightly less than that of the cord blood. It changed little after 3 days of age. Previous studies have shown a transient TSH surge in the first 24-48 hour of life. TSH surge was not apparent in our study because samples were not obtained from infants <24 hours old. Therefore, if TSH is measured for screening of congenital hypothyroidism, samples should be obtained from umbilical cord or infants aged >48 hours. Conclusions: This study provides the normative data for thyroid function tests in Thai full-term neonates. These data are useful for detection and verification of hypothyroidism in a screening program for congenital hypothyroidism.