Publication: Efficacy and safety of rosuvastatin in late-onset hypogonadism patients with dyslipidaemia
Issued Date
2014-01-01
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ISSN
14390272
03034569
03034569
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2-s2.0-84897074615
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Mahidol University
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SCOPUS
Bibliographic Citation
Andrologia. Vol.46, No.4 (2014), 430-436
Suggested Citation
S. Kangwanvanich, S. Permpongkosol Efficacy and safety of rosuvastatin in late-onset hypogonadism patients with dyslipidaemia. Andrologia. Vol.46, No.4 (2014), 430-436. doi:10.1111/and.12099 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33365
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Title
Efficacy and safety of rosuvastatin in late-onset hypogonadism patients with dyslipidaemia
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Abstract
Summary: Rosuvastatin has been used for treatment of dyslipidaemia and metabolic syndrome, but the efficacy has not yet been tested in men with late-onset hypogonadism (LOH). To assess and compare the efficacy and safety of rosuvastatin in men with dyslipidaemia with LOH and non-LOH, a retrospective study was conducted in patients who received rosuvastatin 10 mg day-1 from the men's health clinic. The primary endpoint was the change in low-density lipoprotein (LDL)-cholesterol (C) after 24 weeks of treatment. A total of 145 dyslipidaemic patients eligible for rosuvastatin treatment were enrolled and divided into LOH group (45.52%) and non-LOH (54.48%) group. There were favourable changes in the lipid profiles. In the LOH group whose serum testosterone had been raised by testosterone administration, the favourable changes of the lipids were of similar magnitude as in the non-LOH group. The percentage of patients reaching the target goal (LDL < 100 mg dL-1) did not differ significantly between the group of non-LOH and LOH men treated with testosterone. Side effects were noted in 1/145 men. It is concluded that rosuvastatin was safe and effective in lowering low-density lipoprotein cholesterol in both non-LOH and LOH dyslipidaemic patients whose serum testosterone levels had normalised. © 2013 Blackwell Verlag GmbH.