Publication: Serological evidence for the co-circulation of multiple dengue virus serotypes in Singapore
Issued Date
2005-08-01
Resource Type
ISSN
09502688
Other identifier(s)
2-s2.0-22544479767
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Epidemiology and Infection. Vol.133, No.4 (2005), 667-671
Suggested Citation
Annelies Wilder-Smith, Sutee Yoksan, Arul Earnest, Ravathi Subramaniam, Nicholas I. Paton Serological evidence for the co-circulation of multiple dengue virus serotypes in Singapore. Epidemiology and Infection. Vol.133, No.4 (2005), 667-671. doi:10.1017/S0950268805003821 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16895
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Title
Serological evidence for the co-circulation of multiple dengue virus serotypes in Singapore
Abstract
We did a seroepidemiological study to determine the circulating dengue virus serotypes and the extent to which the Singapore population has been exposed to multiple dengue virus serotypes, using the plaque reduction neutralization assay (PRNT). Of 164 enrolled subjects aged between 18-30 years, 49 subjects (29.8%) were PRNT positive for at least one dengue serotype. The seroprevalence was 39 (23.8%) for dengue virus serotype 1, 37 (22.6%) for type 2, 43 (26.2%) for type 3, and 30 (18.3%) for type 4. Of the 49 subjects with PRNT-positive dengue virus results, 28 (57.1%) were positive to all four virus serotypes, seven (14.3%) to three serotypes, two (4%) to two serotypes, and 12 (24.5%) to a single serotype. All four dengue virus serotypes circulate in Singapore, and a substantial proportion of the adult population in Singapore had exposure to more than one dengue virus serotype. In spite of multiple circulating types, the rate of dengue haemorrhagic fever is low in Singapore. © 2005 Cambridge University Press.