Publication: HLA-A, -B, -DRB1, -DQA1, and -DQB1 polymorphism in Thais
Issued Date
1997-04-01
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ISSN
01988859
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2-s2.0-0030960866
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Mahidol University
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SCOPUS
Bibliographic Citation
Human Immunology. Vol.53, No.2 (1997), 174-182
Suggested Citation
Dasnayanee Chandanayingyong, Henry A.F. Stephens, Rewadee Klaythong, Monchan Sirikong, Sudchai Udee, Panimon Longta, Rapeepun Chantangpol, Sasitorn Bejrachandra, Ekaraj Rungruang HLA-A, -B, -DRB1, -DQA1, and -DQB1 polymorphism in Thais. Human Immunology. Vol.53, No.2 (1997), 174-182. doi:10.1016/S0198-8859(96)00284-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17971
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Title
HLA-A, -B, -DRB1, -DQA1, and -DQB1 polymorphism in Thais
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Abstract
In this study we examined HLA-A, -B, -DRB1, -DQA1, and -DQB1 gene, allele, and haplotype frequencies in two ethnic Thai populations. We compared these frequencies to the known HLA class I and II allele profiles of non- Thai mainland and insular Southeast (SE) Asians. HLA-A locus gene and allele frequencies, are comparatively homogeneous in both Thai and non-Thai SE Asians. In contrast, HLA-B, -DRB1, -DQAl, and -DQB1 gene and allele frequencies, show more ethnic and geographic variation in SE Asians. Conserved haplotypes, or combinations of linked HLA class I and II alleles were detected in Thais, but at relatively low frequencies. It would appear that ethnic Thais, reflect an admixture of peoples from both the northern mainland and southern island groups of SE Asia.