Publication: Activated platelets and leukocyte activations in young patients with β-thalassemia/HbE following bone marrow transplantation
Issued Date
2018-09-01
Resource Type
ISSN
18792472
00493848
00493848
Other identifier(s)
2-s2.0-85049598691
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Mahidol University
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SCOPUS
Bibliographic Citation
Thrombosis Research. Vol.169, (2018), 8-14
Suggested Citation
Phatchanat Klaihmon, Surapong Lertthammakiat, Usanarat Anurathapan, Samart Pakakasama, Nongnuch Sirachainan, Suradej Hongeng, Kovit Pattanapanyasat Activated platelets and leukocyte activations in young patients with β-thalassemia/HbE following bone marrow transplantation. Thrombosis Research. Vol.169, (2018), 8-14. doi:10.1016/j.thromres.2018.07.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46383
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Title
Activated platelets and leukocyte activations in young patients with β-thalassemia/HbE following bone marrow transplantation
Abstract
© 2018 Bone marrow transplantation (BMT) is the only curable option for thalassemia major, β-thalassemia/HbE. However, some patients still have the risk of hypercoagulable complications. We used a whole blood flow cytometric analysis to measure the circulating microparticle (MP) levels, activated platelets, and leukocyte-platelet aggregates in 59 young β-thalassemia/HbE patients compared with 20- and 28-matched healthy and patients receiving regular blood transfusion (RT), respectively. Results from the studies showed that blood samples from BMT group contained a significantly higher numbers of circulating MPs originated from platelets (ann-V + CD41a + ), leukocyte (ann-V + CD45 + ) and endothelial cells (ann-V + CD146 + ) when compared to samples from healthy subjects and RT patients. In contrast, the percentages of activated/procoagulant platelets (CD62P and CD142 expressing platelets) were decreased in BMT group. In addition, monocytes forming microaggregates were the major population among other leukocyte-platelet complexes. Different patterns of CD11b, CD62P and CD142 expression on platelet-leukocyte microaggregate surface were also found. These data suggest that circulating MPs together with leukocyte-platelet aggregates may be responsible, in part, in pathogenesis of hypercoagulable state in β-thalassemia/HbE patients who undergone BMT.