Publication: Incidence and risk factors of major opportunistic infections after initiation of antiretroviral therapy among advanced HIV-infected patients in a resource-limited setting
Issued Date
2007-11-01
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ISSN
01634453
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2-s2.0-35348971860
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infection. Vol.55, No.5 (2007), 464-469
Suggested Citation
Weerawat Manosuthi, Achara Chaovavanich, Somsit Tansuphaswadikul, Wisit Prasithsirikul, Yoawarat Inthong, Suthat Chottanapund, Chayanan Sittibusaya, Visal Moolasart, Patamavadee Termvises, Somnuek Sungkanuparph Incidence and risk factors of major opportunistic infections after initiation of antiretroviral therapy among advanced HIV-infected patients in a resource-limited setting. Journal of Infection. Vol.55, No.5 (2007), 464-469. doi:10.1016/j.jinf.2007.07.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24706
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Title
Incidence and risk factors of major opportunistic infections after initiation of antiretroviral therapy among advanced HIV-infected patients in a resource-limited setting
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Abstract
Objective: To study incidence, risk factors, and impact of major opportunistic infections (OIs) after initiation of antiretroviral therapy (ART). Methods: A retrospective cohort study was conducted among naïve HIV-infected patients who were initiated ART during January 2003-December 2004. All patients were followed until 15 months after ART. Results: There were 793 patients with mean ± SD age of 35.2 ± 7.4 years and 56.3% male. Median (IQR) CD4 was 26 (9-78) cells/mm3. Of 793 patients, 61 (8%) patients developed 81 episodes of OIs after ART. These included tuberculosis (48.1%), CMV retinitis (19.8%), MAC infection (14.8%), PCP (9.9%), cryptococcosis (6.2%) and penicilliosis (1.2%). Overall incidence of new episode of OIs after ART was 8.0% during the first year of ART. Probabilities of OIs at 1, 2, 3, 6, and 12 months after ART were 2.6%, 4.0%, 5.3%, 6.9% and 8.0%, respectively. Baseline CD4 ≤50 cells/mm3, male gender, and low body weight were associated with higher incidence of OIs after ART (P < 0.05). Conclusions: Most of new episodes of major OIs develop within the first three months after ART. Tuberculosis is the most frequent OIs in this situation. The substantial increase of new episode of OIs after ART was observed among HIV-infected patients with CD4 cell counts ≤50 cells/mm3at ART initiation. © 2007 The British Infection Society.