Publication: Association of statin therapy with ventricular arrhythmias among patients with acute coronary syndrome
Issued Date
2013-07-11
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17591104
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2-s2.0-84879829375
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Mahidol University
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SCOPUS
Bibliographic Citation
Heart Asia. Vol.5, No.1 (2013), 39-41
Suggested Citation
Sirin Apiyasawat, Piyamitr Sritara, Tachapong Ngarmukos, Charn Sriratanasathavorn, Piya Kasemsuwan Association of statin therapy with ventricular arrhythmias among patients with acute coronary syndrome. Heart Asia. Vol.5, No.1 (2013), 39-41. doi:10.1136/heartasia-2012-010225 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32262
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Title
Association of statin therapy with ventricular arrhythmias among patients with acute coronary syndrome
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Abstract
Background: In addition to lowering cholesterol, statins stabilise atherosclerotic plaques and can potentially reduce the incidence of ventricular arrhythmias. We tested the hypothesis that prior statin therapy is associated with a lower incidence of inhospital ventricular arrhythmias among patients with acute coronary syndrome (ACS). Methods: The study population consisted of 2007 patients (mean age 64 years, 67.5% male) enrolled in the Thai Registry of Acute Coronary Syndrome, a prospective, multicentre, nationwide, observational study of patients with ACS. Patients were categorised as either statin users or non-users according to their reports of statin use before enrolment at their initial presentation. The primary endpoint was inhospital ventricular arrhythmias. The secondary endpoint was a composite endpoint of inhospital ventricular arrhythmias or inhospital cardiac death. A propensity-adjusted multivariate model was developed to assess the effects of statin use on the primary and secondary endpoints. Results: During a mean hospital stay of 7 days, a total of 96 patients (4.8%) died; 82 (4.1%) of the deaths were due to cardiac causes. The primary and secondary endpoints were reached in 163 patients (8.1%) and 194 patients (9.7%), respectively. A total of 525 patients (26.2%) had used statins prior to hospitalisation. After adjusting for the propensity scores and other relevant covariates, statin use was associated with lower risks of the primary (adjusted OR 0.505, 95% CI 0.276 to 0.923) and secondary endpoints (adjusted OR 0.498, 95% CI 0.276 to 0.897). Conclusions: The use of statins is associated with a reduced incidence of ventricular arrhythmias among patients with ACS.