Publication: Other 4-methanolquinolines, amyl alcohols and phentathrenes: Mefloquine, lumefantrine and halofantrine
Issued Date
2012-01-01
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2-s2.0-85028284708
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Mahidol University
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SCOPUS
Bibliographic Citation
Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. (2012), 95-111
Suggested Citation
Francois Nosten, Penelope A. Phillips-Howard, Feiko O. ter Kuile Other 4-methanolquinolines, amyl alcohols and phentathrenes: Mefloquine, lumefantrine and halofantrine. Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. (2012), 95-111. doi:10.1007/978-3-0346-0480-2_5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15114
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Title
Other 4-methanolquinolines, amyl alcohols and phentathrenes: Mefloquine, lumefantrine and halofantrine
Abstract
© Springer Basel AG 2011. This chapter describes mefloquine, pyronaridine, halofantrine, piperaquine and lumefantrine under the broader title of the 4-methanolquinolines, amyl alcohols and phentathrenes. We provide a brief resume of each drug, in terms of their chemical properties, formulae, pharmacokinetics, clinical indications for use, and their efficacy and safety. Recognizing the limited number of antimalarials available, and in the developmental pipeline, attention is focussed on describing the history of each drug and how their indications have evolved as data on safety in human populations accumulates over time, and how patterns of use have changed with growing multiple drug resistance. Their combined use with the artemisinin derivatives is briefly described and readers are recommended to consult other chapters in this book which more fully describe such combinations.