Publication: Epstein-barr virus mediated signaling in nasopharyngeal carcinoma carcinogenesis
Issued Date
2020-09-01
Resource Type
ISSN
20726694
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2-s2.0-85091988116
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Mahidol University
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SCOPUS
Bibliographic Citation
Cancers. Vol.12, No.9 (2020), 1-23
Suggested Citation
Timmy Richardo, Pongphol Prattapong, Chawalit Ngernsombat, Nurulfitri Wisetyaningsih, Hisashi Iizasa, Hironori Yoshiyama, Tavan Janvilisri Epstein-barr virus mediated signaling in nasopharyngeal carcinoma carcinogenesis. Cancers. Vol.12, No.9 (2020), 1-23. doi:10.3390/cancers12092441 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/59880
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Title
Epstein-barr virus mediated signaling in nasopharyngeal carcinoma carcinogenesis
Abstract
© MDPI AG. All rights reserved. Nasopharyngeal carcinoma (NPC) is one of the most common tumors occurring in China and Southeast Asia. Etiology of NPC seems to be complex and involves many determinants, one of which is Epstein-Barr virus (EBV) infection. Although evidence demonstrates that EBV infection plays a key role in NPC carcinogenesis, the exact relationship between EBV and dysregulation of signaling pathways in NPC needs to be clarified. This review focuses on the interplay between EBV and NPC cells and the corresponding signaling pathways, which are modulated by EBV oncoproteins and non-coding RNAs. These altered signaling pathways could be critical for the initiation and progression of NPC.