Publication: Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm?
Issued Date
2020-01-01
Resource Type
ISSN
14715007
14714922
14714922
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2-s2.0-85092462613
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Mahidol University
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SCOPUS
Bibliographic Citation
Trends in Parasitology. (2020)
Suggested Citation
Rob W. van der Pluijm, Chanaki Amaratunga, Mehul Dhorda, Arjen M. Dondorp Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm?. Trends in Parasitology. (2020). doi:10.1016/j.pt.2020.09.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/59998
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Title
Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm?
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Abstract
© 2020 The Authors Recent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-based combination therapies have shown reduced efficacy in some countries in the GMS at some point. Novel drugs are not available for the near future. Triple artemisinin-based combination therapies, combining artemisinins with two currently available partner drugs, will provide one of the last remaining safe and effective treatments for falciparum malaria that can be deployed rapidly in the GMS, whereas their deployment beyond the GMS could delay or prevent the global emergence and spread of resistance to currently available drugs.