Publication: Hypervitaminosis A in rats. Varying responses due to different forms, doses, and routes of administration
Issued Date
1973-12-01
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ISSN
00039985
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2-s2.0-0015833616
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Pathology and Laboratory Medicine. Vol.96, No.1 (1973), 5-9
Suggested Citation
V. Leelaprute, V. Boonpucknavig, N. Bhamarapravati, W. Weerapradist Hypervitaminosis A in rats. Varying responses due to different forms, doses, and routes of administration. Archives of Pathology and Laboratory Medicine. Vol.96, No.1 (1973), 5-9. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/10129
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Title
Hypervitaminosis A in rats. Varying responses due to different forms, doses, and routes of administration
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Abstract
A study made on rats after excessive vitamin A treatment showed that the mortality, bone lesions, and calcification of organs are related to at least three factors, i.e., forms of vitamin A (vitamin A palmitate or vitamin A alcohol), doses (25,000, 50,000, and 75,000 international units (IU)/rat/day), and routes of administration (intraperitoneal or oral). In rats that received vitamin A palmitate by intraperitoneal route, there was no clinical toxicity, no bone lesion, nor soft tissue calcification, but oral administration of vitamin A palmitate of the same dose produced clinical toxicity with bone lesion and soft tissue calcification. Clinical toxicity, bone damage, and tissue calcification developed in animals that received vitamin A alcohol by both routes. The intraperitoneal administration produced more toxicity and more tissue damage in rats than the oral administration.