Publication: Brain-kidney crosstalk
Issued Date
2014-06-05
Resource Type
ISSN
1466609X
13648535
13648535
DOI
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2-s2.0-84902002914
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Mahidol University
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SCOPUS
Bibliographic Citation
Critical Care. Vol.18, No.3 (2014)
Suggested Citation
Arkom Nongnuch, Kwanpeemai Panorchan, Andrew Davenport Brain-kidney crosstalk. Critical Care. Vol.18, No.3 (2014). doi:10.1186/cc13907 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34242
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Title
Brain-kidney crosstalk
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Abstract
Encephalopathy and altered higher mental functions are common clinical complications of acute kidney injury. Although sepsis is a major triggering factor, acute kidney injury predisposes to confusion by causing generalised inflammation, leading to increased permeability of the blood-brain barrier, exacerbated by hyperosmolarity and metabolic acidosis due to the retention of products of nitrogen metabolism potentially resulting in increased brain water content. Downregulation of cell membrane transporters predisposes to alterations in neurotransmitter secretion and uptake, coupled with drug accumulation increasing the risk of encephalopathy. On the other hand, acute brain injury can induce a variety of changes in renal function ranging from altered function and electrolyte imbalances to inflammatory changes in brain death kidney donors. © 2014 Nongnuch et al.; licensee BioMed Central Ltd.