Publication: Elective cesarean delivery plus short-course lamivudine and zidovudine for the prevention of mother-to-child transmission of human immunodeficiency virus type 1
Issued Date
2004-01-01
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ISSN
00029378
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2-s2.0-1642423620
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Obstetrics and Gynecology. Vol.190, No.3 (2004), 803-808
Suggested Citation
Panyu Panburana, Sayomporn Sirinavin, Winit Phuapradit, Asda Vibhagool, Wasun Chantratita Elective cesarean delivery plus short-course lamivudine and zidovudine for the prevention of mother-to-child transmission of human immunodeficiency virus type 1. American Journal of Obstetrics and Gynecology. Vol.190, No.3 (2004), 803-808. doi:10.1016/j.ajog.2003.09.034 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21750
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Title
Elective cesarean delivery plus short-course lamivudine and zidovudine for the prevention of mother-to-child transmission of human immunodeficiency virus type 1
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Abstract
Objective: The purpose of this study was to evaluate the effect of elective cesarean delivery plus a lamivudine-zidovudine prophylaxis regimen on non-breastfeeding mothers with human immunodeficiency virus type 1 and their infants. Study design: Forty-six antiretroviral-naïve, pregnant women with human immunodeficiency virus type 1 were included. The prophylactic regimen was a lamivudine-zidovudine tablet (150 mg/ 300 mg) twice daily from week 34 of pregnancy until cesarean delivery at week 38 of gestation, preoperative intravenous zidovudine, and neonatal zidovudine syrup for 4 weeks. Results: At weeks 34 and 38 of gestation, the median maternal viral loads were, respectively, 3.65 log10copies/mL (range, 2.34-4.70 log10copies/mL) and 2.51 log10copies/mL (range, 2.04-3.66 log10copies/mL; P<.001), respectively; the viral reduction was 1.12 log10copies/mL (range, -0.16-2.60 log10copies/mL), and the CD4+cell counts increased from 335 cells/mm3(range, 57-974 cells/mm3) to 420 cells/mm3(range, 84-1,083 cells/mm3; P = .002). No mother or infant had a serious adverse event. Two infants were infected (4.3%; 95% CI, 0 .5%-15.7%); 1 infant had intrapartum infection. Conclusion: Elective cesarean delivery plus short-course lamivudine-zidovudine is safe but does not eliminate mother-to-child transmission of human immunodeficiency virus type 1. © 2004 Elsevier Inc. All rights reserved.