Publication: Cytogenetic effect of bleomycin on human leukocytes in vitro
Issued Date
1975-01-01
Resource Type
ISSN
00275107
Other identifier(s)
2-s2.0-0016640505
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Mahidol University
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SCOPUS
Bibliographic Citation
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Vol.28, No.1 (1975), 107-112
Suggested Citation
C. Promchainant Cytogenetic effect of bleomycin on human leukocytes in vitro. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Vol.28, No.1 (1975), 107-112. doi:10.1016/0027-5107(75)90320-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/10743
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Title
Cytogenetic effect of bleomycin on human leukocytes in vitro
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Abstract
Human leukocytes treated with bleomycin (BLM) for clinical use, at concentrations of 0.1, 0.5, 1.0, 10 and 50 μg/ml were studied. Both chromosome- and chromatid-type aberrations were observed. The groups of larger chromosomes were more affected at every concentration. At dosages from 0.1 to 10 μ/ml no significant difference of effects on chromosomes was observed. However, a dose-difference of about 500 times showed significant differences in effect both on the degree of chromosomal aberration and on mitotic indices. © 1975.