Publication: Antimalarial 20-membered macrolides from Streptomyces sp. BCC33756
| dc.contributor.author | Aibrohim Dramae | en_US |
| dc.contributor.author | Sutichai Nithithanasilp | en_US |
| dc.contributor.author | Wilunda Choowong | en_US |
| dc.contributor.author | Pranee Rachtawee | en_US |
| dc.contributor.author | Samran Prabpai | en_US |
| dc.contributor.author | Palangpon Kongsaeree | en_US |
| dc.contributor.author | Pattama Pittayakhajonwut | en_US |
| dc.contributor.other | Thailand National Center for Genetic Engineering and Biotechnology | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-10-19T04:35:56Z | |
| dc.date.available | 2018-10-19T04:35:56Z | |
| dc.date.issued | 2013-09-23 | en_US |
| dc.description.abstract | Two new natural products, samroiyotmycins A (1) and B (2), along with two naturally new novclobiocin 101 (3) and 4-hydroxy-3-(3-methylbut-2-enyl)benzamide (5), and five known substances including neoantimycin, clorobiocin (4), 29-O-methylabierixin, daidzein, and 1-(3-indolyl)-2,3-dihydroxypropan-1-one have been isolated from Streptomyces sp. BCC33756. Their chemical structures were determined based on NMR spectral information and the relative stereochemistry of compound 1 was determined by X-ray crystallographic data. Both samroiyotmycins A and B exhibited antimalarial activity against Plasmodium falciparum K1 - multi-drug resistant strain, with IC50values of 3.65 and 3.16 μg/mL, respectively. Compound 1 was inactive against both cancerous (MCF-7, KB) and non-cancerous (Vero) cells, while compound 2 displayed cytotoxicity against Vero cell with IC50value of 29.57 μg/mL. © 2013 Published by Elsevier Ltd. | en_US |
| dc.identifier.citation | Tetrahedron. Vol.69, No.38 (2013), 8205-8208 | en_US |
| dc.identifier.doi | 10.1016/j.tet.2013.07.034 | en_US |
| dc.identifier.issn | 14645416 | en_US |
| dc.identifier.issn | 00404020 | en_US |
| dc.identifier.other | 2-s2.0-84881183298 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/31211 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84881183298&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Antimalarial 20-membered macrolides from Streptomyces sp. BCC33756 | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84881183298&origin=inward | en_US |