Publication: Role of surgery in oligometastatic prostate cancer
Issued Date
2019-12-01
Resource Type
ISSN
2287903X
22878882
22878882
Other identifier(s)
2-s2.0-85077374820
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Prostate International. Vol.7, No.4 (2019), 125-130
Suggested Citation
Pocharapong Jenjitranant, Karim A. Touijer Role of surgery in oligometastatic prostate cancer. Prostate International. Vol.7, No.4 (2019), 125-130. doi:10.1016/j.prnil.2019.10.001 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51267
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Role of surgery in oligometastatic prostate cancer
Author(s)
Abstract
© 2020 Androgen deprivation therapy as single modality therapy was the standard management for oligometastatic prostate cancer (PCa). Current paradigm shifts toward a multimodality therapy approach, targeting all sites of disease, including treatment of the primary in the form of radical prostatectomy or radiation therapy. The objective of this article was to reveiw the literature regarding the role of surgery in oligometastatic PCa. PubMed and MEDLINE electronic databases were queried for English language articles from January 1, 1980 to March 31, 2019. Keywords use included oligometastatic PCa, metastatic prostate cancer (mPCa), radical prostatectomy, and cytoreductive prostatectomy. Preclinical, prospective, and retrospective studies were included. There is no published randomized controlled trials, evaluating the role of surgery in mPCa. Preclinical and retrospective data suggest benefit of primary tumor treatment in mPCa. Current literature supports the concept of cytoreductive surgery as it can prevent late symptomatic local progression, has acceptable complications, and may prolong survival in patients with mPCa. Surgery is a feasible procedure in mPCa which may improve outcome in mPCa. However, there is no Level 1 evidence, yet that support the role of surgery in mPCa. The results from well-organized prospective, randomized controlled trials are awaited before performing radical prostatectomy for mPCa in clinical practice.
