Publication: Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp
Issued Date
2008-07-01
Resource Type
ISSN
09680896
Other identifier(s)
2-s2.0-44749084695
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Bioorganic and Medicinal Chemistry. Vol.16, No.13 (2008), 6560-6567
Suggested Citation
Veena S. Nukoolkarn, Suwipa Saen-oon, Thanyada Rungrotmongkol, Supot Hannongbua, Kornkanok Ingkaninan, Khanit Suwanborirux Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp. Bioorganic and Medicinal Chemistry. Vol.16, No.13 (2008), 6560-6567. doi:10.1016/j.bmc.2008.05.027 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18901
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp
Abstract
Two pyridoacridine alkaloids, including a known petrosamine and a new 2-bromoamphimedine were isolated from a Thai marine sponge Petrosia n. sp. The alkaloids were characterized on the basis of 1D and 2D NMR, MS, and IR spectroscopy. Only petrosamine showed strong acetylcholinesterase inhibitory activity approximately six times higher than that of the reference galanthamine. A computational docking study of petrosamine with the enzyme from the electric eel Torpedo californica (TcAChE) showed the major contribution to the petrosamine-TcAChE interaction to be arising from the quaternary ammonium group of petrosamine. © 2008 Elsevier Ltd. All rights reserved.