Publication:
A rapid and simple method for routine determination of antibiotic sensitivity to biofilm populations of Pseudomonas aeruginosa

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dc.contributor.authorDhammika Leshan Wannigamaen_US
dc.contributor.authorCameron Hursten_US
dc.contributor.authorParichart Hongsingen_US
dc.contributor.authorLachlan Pearsonen_US
dc.contributor.authorThammakorn Saethangen_US
dc.contributor.authorNaphat Chantaravisooten_US
dc.contributor.authorUthaibhorn Singkham-Inen_US
dc.contributor.authorSirirat Luk-Inen_US
dc.contributor.authorRobin James Storeren_US
dc.contributor.authorTanittha Chatsuwanen_US
dc.contributor.otherUniversity of Western Australiaen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherQIMR Berghofer Medical Research Instituteen_US
dc.contributor.otherKasetsart Universityen_US
dc.contributor.otherMae Fah Luang Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThe Westmead Institute for Medical Researchen_US
dc.date.accessioned2020-05-05T05:38:19Z
dc.date.available2020-05-05T05:38:19Z
dc.date.issued2020-03-13en_US
dc.description.abstract© 2020 The Author(s). Treatment of infections by Pseudomonas aeruginosa forming biofilms after antimicrobial testing on planktonic bacteria can result in substantial failure. Therefore, we offer a robust and simple experimental platform to test the impact of antimicrobials on biofilms. Antibiotic response patterns varied uniquely within biofilm formation capacity and minimal biofilm eradication concentrations (MBECs) has a significantly better discriminatory power than minimum inhibitory concentrations (MICs) to differentiate the overall efficiency of antibiotics to eradicate biofilm. Our resazurin-based 96-well-plate platform is able to emulate bacterial responses to antibiotics under biofilm conditions in a fast, simple, and cost-effective screening method adaptable to automation, and warrants trials in the clinic.en_US
dc.identifier.citationAnnals of Clinical Microbiology and Antimicrobials. Vol.19, No.1 (2020)en_US
dc.identifier.doi10.1186/s12941-020-00350-6en_US
dc.identifier.issn14760711en_US
dc.identifier.other2-s2.0-85081976448en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/54619
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081976448&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleA rapid and simple method for routine determination of antibiotic sensitivity to biofilm populations of Pseudomonas aeruginosaen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081976448&origin=inwarden_US

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