Publication: Effects of Stevioside and Steviol on Intestinal Glucose Absorption in Hamsters
Issued Date
1995-01-01
Resource Type
ISSN
18817742
03014800
03014800
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2-s2.0-0028954170
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Nutritional Science and Vitaminology. Vol.41, No.1 (1995), 105-113
Suggested Citation
Chaivat Toskulkao, Monthaporn Sutheerawatananon, Chaitip Wanichanon, Porncharn Saitongdee, Maitree Suttajit Effects of Stevioside and Steviol on Intestinal Glucose Absorption in Hamsters. Journal of Nutritional Science and Vitaminology. Vol.41, No.1 (1995), 105-113. doi:10.3177/jnsv.41.105 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17486
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Title
Effects of Stevioside and Steviol on Intestinal Glucose Absorption in Hamsters
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Abstract
The effects of stevioside and steviol (a product of enzymatic hydrolysis of stevioside) on intestinal glucose absorption were examined in the hamster jejunum in vitro. By using the jejunal rings technique, we found that stevioside at a high dose of 5mM had no inhibitory effect on glucose absorption. In contrast, glucose absorption was inhibited 43% by 1 mM steviol. The inhibition of glucose absorption by steviol was related to steviol concentration and incubation time. The inhibitory effect of steviol compared to phlorizin and ouabain was also investigated. Steviol, which caused a decrease in glucose accumulation in the intestinal ring tissues, possibly acts on the brush border membrane as does phlorizin. Furthermore, it was also found that steviol altered the morphology of the intestinal absorptive cells. These results suggest that the possible site of inhibitory action of steviol might be on the mucosal side and/or at the intracellular organelles of intestinal absorptive cells. © 1995, Center for Academic Publications Japan. All rights reserved.