Publication: Chlorpheniramine attenuated hypertensive effect of phenylpropanolamine in rats
Issued Date
2012
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Language
eng
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application/pdf
No. of Pages/File Size
804 KB
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Mahdiol University
Rights Holder(s)
Asian Association of Schools of Pharmacy
Bibliographic Citation
Journal of Asian Association of Schools of Pharmacy. 2012;Vol.1, No.4 (2012), 226-34.
Suggested Citation
Saowaluk Sawangdee, Yuvadee Wongkrajang, Suchitra Thongpraditchote, Penchom Peungvicha, Boonthium Kongsaktrakoon, Chuthamanee Suthisisang, เสาวลักษณ์ สว่างดี, ยุวดี วงษ์กระจ่าง, สุจิตรา ทองประดิษฐ์โชติ, เพ็ญโฉม พึ่งวิชา, บุญเทียม คงศักดิ์ตระกูล, จุฑามณี สุทธิสีสังข์ Chlorpheniramine attenuated hypertensive effect of phenylpropanolamine in rats. Journal of Asian Association of Schools of Pharmacy. 2012;Vol.1, No.4 (2012), 226-34.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/62559
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Title
Chlorpheniramine attenuated hypertensive effect of phenylpropanolamine in rats
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Abstract
Phenylpropanolamine (PPA) is a sympathomimetic drug that exerts its effect mainly through the alphaadrenergic receptor. A pharmacoepidemiological study reported by the hemorrhagic stroke project in the year 2000 suggested an association between high dose PPA and hemorrhagic stroke. However, the hemodynamic effect of PPA might be altered in the presence of chlorpheniramine (CPM) as used in over-the-counter cold remedy (PPA, 0.3 mg/kg plus CPM, 0.04 mg/kg). It was found that PPA (5-30 times that used in humans) dose-dependently increased in blood pressure in rats and this effect was antagonized by CPM in male rats and non-proestrous female rats but not in proestrous female rats. The hypertensive effect of PPA could not be antagonized by loratadine, a highly specific H1 blocker.