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Chlorpheniramine attenuated hypertensive effect of phenylpropanolamine in rats

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dc.contributor.authorSaowaluk Sawangdeeen_US
dc.contributor.authorYuvadee Wongkrajangen_US
dc.contributor.authorSuchitra Thongpraditchoteen_US
dc.contributor.authorPenchom Peungvichaen_US
dc.contributor.authorBoonthium Kongsaktrakoonen_US
dc.contributor.authorChuthamanee Suthisisangen_US
dc.contributor.authorเสาวลักษณ์ สว่างดีen_US
dc.contributor.authorยุวดี วงษ์กระจ่างen_US
dc.contributor.authorสุจิตรา ทองประดิษฐ์โชติen_US
dc.contributor.authorเพ็ญโฉม พึ่งวิชาen_US
dc.contributor.authorบุญเทียม คงศักดิ์ตระกูลen_US
dc.contributor.authorจุฑามณี สุทธิสีสังข์en_US
dc.contributor.correspondenceYuvadee Wongkrajangen_US
dc.contributor.otherMahdiol University. Faculty of Pharmacy. Department of Physiologyen_US
dc.contributor.otherMahdiol University. Faculty of Pharmacy. Department of Pharmacologyen_US
dc.date.accessioned2015-03-28T10:19:31Z
dc.date.accessioned2021-06-02T03:01:13Z
dc.date.available2015-03-28T10:19:31Z
dc.date.available2021-06-02T03:01:13Z
dc.date.created2015
dc.date.issued2012
dc.description.abstractPhenylpropanolamine (PPA) is a sympathomimetic drug that exerts its effect mainly through the alphaadrenergic receptor. A pharmacoepidemiological study reported by the hemorrhagic stroke project in the year 2000 suggested an association between high dose PPA and hemorrhagic stroke. However, the hemodynamic effect of PPA might be altered in the presence of chlorpheniramine (CPM) as used in over-the-counter cold remedy (PPA, 0.3 mg/kg plus CPM, 0.04 mg/kg). It was found that PPA (5-30 times that used in humans) dose-dependently increased in blood pressure in rats and this effect was antagonized by CPM in male rats and non-proestrous female rats but not in proestrous female rats. The hypertensive effect of PPA could not be antagonized by loratadine, a highly specific H1 blocker.en_US
dc.format.extent804 KB
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Asian Association of Schools of Pharmacy. 2012;Vol.1, No.4 (2012), 226-34.en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/62559
dc.language.isoengen_US
dc.rightsMahdiol Universityen_US
dc.rights.holderAsian Association of Schools of Pharmacyen_US
dc.subjectPhenylpropanolamineen_US
dc.subjectChlorpheniramineen_US
dc.subjectBlood Pressureen_US
dc.subjectSympathomimetic drugen_US
dc.subjectHemorrhagic strokeen_US
dc.titleChlorpheniramine attenuated hypertensive effect of phenylpropanolamine in ratsen_US
dc.typeResearch Articleen_US
dspace.entity.typePublication

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