Publication:
Early life risk factors of motor, cognitive and language development: A pooled analysis of studies from low/middle-income countries

Issued Date

2019-10-01

Resource Type

Article

ISSN

20446055

DOI

10.1136/bmjopen-2018-026449

Other identifier(s)

2-s2.0-85072932180

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

BMJ Open. Vol.9, No.10 (2019)

Suggested Citation

Ayesha Sania, Christopher R. Sudfeld, Goodarz Danaei, Günther Fink, Dana C. McCoy, Zhaozhong Zhu, Mary C.Smith Fawzi, Mehmet Akman, Shams E. Arifeen, Aluisio J.D. Barros, David Bellinger, Maureen M. Black, Alemtsehay Bogale, Joseph M. Braun, Nynke Van Den Broek, Verena Carrara, Paulita Duazo, Christopher Duggan, Lia C.H. Fernald, Melissa Gladstone, Jena Hamadani, Alexis J. Handal, Siobán Harlow, Melissa Hidrobo, Chris Kuzawa, Ingrid Kvestad, Lindsey Locks, Karim Manji, Honorati Masanja, Alicia Matijasevich, Christine McDonald, Rose McGready, Arjumand Rizvi, Darci Santos, Leticia Santos, Dilsad Save, Roger Shapiro, Barbara Stoecker, Tor A. Strand, Sunita Taneja, Martha Maria Tellez-Rojo, Fahmida Tofail, Aisha K. Yousafzai, Majid Ezzati, Wafaie Fawzi Early life risk factors of motor, cognitive and language development: A pooled analysis of studies from low/middle-income countries. BMJ Open. Vol.9, No.10 (2019). doi:10.1136/bmjopen-2018-026449 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51408

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Title

Early life risk factors of motor, cognitive and language development: A pooled analysis of studies from low/middle-income countries

Author(s)

Ayesha Sania
 Christopher R. Sudfeld
 Goodarz Danaei
 Günther Fink
 Dana C. McCoy
 Zhaozhong Zhu
 Mary C.Smith Fawzi
 Mehmet Akman
 Shams E. Arifeen
 Aluisio J.D. Barros
 David Bellinger
 Maureen M. Black
 Alemtsehay Bogale
 Joseph M. Braun
 Nynke Van Den Broek
 Verena Carrara
 Paulita Duazo
 Christopher Duggan
 Lia C.H. Fernald
 Melissa Gladstone
 Jena Hamadani
 Alexis J. Handal
 Siobán Harlow
 Melissa Hidrobo
 Chris Kuzawa
 Ingrid Kvestad
 Lindsey Locks
 Karim Manji
 Honorati Masanja
 Alicia Matijasevich
 Christine McDonald
 Rose McGready
 Arjumand Rizvi
 Darci Santos
 Leticia Santos
 Dilsad Save
 Roger Shapiro
 Barbara Stoecker
 Tor A. Strand
 Sunita Taneja
 Martha Maria Tellez-Rojo
 Fahmida Tofail
 Aisha K. Yousafzai
 Majid Ezzati
 Wafaie Fawzi

Other Contributor(s)

NORCE Norwegian Research Centre AS
 Ifakara Health Institute
 University of Dar Es Salaam
 University of San Carlos
 The Aga Khan University Hospital
 Society for Applied Studies Kolkata
 Instituto Nacional de Perinatologia
 Shoklo Malaria Research Unit
 University of New Mexico
 Harvard T.H. Chan School of Public Health
 Children's Hospital Boston
 Harvard Graduate School of Education
 Columbia University Irving Medical Center
 University of California, Berkeley
 Liverpool School of Tropical Medicine
 University of Liverpool
 University of Michigan School of Public Health
 Imperial College London
 University of Maryland, Baltimore
 Universidade Federal de Pelotas
 Universidade Federal da Bahia
 Mahidol University
 Brown University
 International Centre for Diarrhoeal Disease Research Bangladesh
 Nuffield Department of Clinical Medicine
 Universidade de Sao Paulo - USP
 Northwestern University
 Oklahoma State University - Stillwater
 Marmara Üniversitesi Tip Fakültesi
 Children's Hospital Oakland Research Institute
 Harvard Medical School
 International Food Policy Research Institute
 Nature's Bounty Co.
 SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT

Abstract

© 2019 Author(s). Objective To determine the magnitude of relationships of early life factors with child development in low/middle-income countries (LMICs). Design Meta-analyses of standardised mean differences (SMDs) estimated from published and unpublished data. Data sources We searched Medline, bibliographies of key articles and reviews, and grey literature to identify studies from LMICs that collected data on early life exposures and child development. The most recent search was done on 4 November 2014. We then invited the first authors of the publications and investigators of unpublished studies to participate in the study. Eligibility criteria for selecting studies Studies that assessed at least one domain of child development in at least 100 children under 7 years of age and collected at least one early life factor of interest were included in the study. Analyses Linear regression models were used to assess SMDs in child development by parental and child factors within each study. We then produced pooled estimates across studies using random effects meta-analyses. Results We retrieved data from 21 studies including 20 882 children across 13 LMICs, to assess the associations of exposure to 14 major risk factors with child development. Children of mothers with secondary schooling had 0.14 SD (95% CI 0.05 to 0.25) higher cognitive scores compared with children whose mothers had primary education. Preterm birth was associated with 0.14 SD (-0.24 to-0.05) and 0.23 SD (-0.42 to-0.03) reductions in cognitive and motor scores, respectively. Maternal short stature, anaemia in infancy and lack of access to clean water and sanitation had significant negative associations with cognitive and motor development with effects ranging from-0.18 to-0.10 SDs. Conclusions Differential parental, environmental and nutritional factors contribute to disparities in child development across LMICs. Targeting these factors from prepregnancy through childhood may improve health and development of children.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/51408

Collections

Scopus 2019