Publication: Plasmodium vivax genetic diversity: microsatellite length matters
Issued Date
2006-09-01
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ISSN
14714922
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2-s2.0-33746783035
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Mahidol University
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SCOPUS
Bibliographic Citation
Trends in Parasitology. Vol.22, No.9 (2006), 399-401
Suggested Citation
Bruce Russell, Rossarin Suwanarusk, Usa Lek-Uthai Plasmodium vivax genetic diversity: microsatellite length matters. Trends in Parasitology. Vol.22, No.9 (2006), 399-401. doi:10.1016/j.pt.2006.06.013 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23308
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Title
Plasmodium vivax genetic diversity: microsatellite length matters
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Abstract
The Plasmodium vivax genome is very diverse but has a relatively low abundance of microsatellites. Leclerc et al. had shown that these di-nucleotide repeats have a low level of polymorphism, suggesting a recent bottleneck event in the evolutionary history of P. vivax. By contrast, in a recent paper, Imwong et al. show that there is a very high level of microsatellite diversity. The difference in these results is probably due to the set array lengths chosen by each group. Longer arrays are more diverse than are shorter ones because slippage mutations become exponentially more common with an increase in array length. These studies highlight the need to consider carefully the application and design of studies involving microsatellites. © 2006 Elsevier Ltd. All rights reserved.