Publication:
'Snakes and ladders' of drug resistance evolution

Issued Date

2011-01-01

Resource Type

Article

ISSN

21505608
21505594

Other identifier(s)

2-s2.0-85011939869

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Virulence. Vol.2, No.3 (2011)

Suggested Citation

Thanat Chookajorn, Krittikorn Kümpornsin 'Snakes and ladders' of drug resistance evolution. Virulence. Vol.2, No.3 (2011). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12090

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Title

'Snakes and ladders' of drug resistance evolution

Author(s)

Thanat Chookajorn
 Krittikorn Kümpornsin

Other Contributor(s)

Mahidol University

Abstract

Malaria is a major public health problem affecting 500 million people each year. Only few anti-malarial drugs are now available for fighting this deadly disease and their effectiveness is alarmingly dwindling because of the drug-resistant strains. Here we discuss recent findings on the evolutionary process behind the gain of a resistant gene. It was shown that for a protein to become resistant to an inhibitor, an intricate stepwise order of mutations must be followed. The projected evolutionary steps were compared with the field data, which reflects the natural history of drug resistant development. © 2011 Landes Bioscience.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/12090

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Scopus 2011-2015