Publication: Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in HIV-seropositive patients and gonococcal antimicrobial susceptibility: An update in Thailand
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Issued Date
2009-12-01
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ISSN
13446304
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2-s2.0-75149117256
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Mahidol University
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SCOPUS
Bibliographic Citation
Japanese Journal of Infectious Diseases. Vol.62, No.6 (2009), 467-470
Suggested Citation
Somporn Srifeungfung, Anuvat Roongpisuthipong, Suvanna Asavapiriyanont, Rangsima Lolekha, Chanwit Tribuddharat, Somchai Lokpichart, Prasong Sungthong, Patrapee Tongtep Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in HIV-seropositive patients and gonococcal antimicrobial susceptibility: An update in Thailand. Japanese Journal of Infectious Diseases. Vol.62, No.6 (2009), 467-470. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27855
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Title
Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in HIV-seropositive patients and gonococcal antimicrobial susceptibility: An update in Thailand
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Abstract
We surveyed the rate of chlamydial and gonococcal infections among human immunodeficiency virus (HIV)-seropositive patients in Thailand as well as the current status of antimicrobial resistance of Neisseria gonorrhoeae and determined the prevalence of penicillinase-producing N. gonorrhoeae (PPNG) in Thailand. A total of 1,158 endocervical swabs from 824 HIV-seropositive patients were collected to detect both organisms by Gen-Probe. The prevalences of chlamydial and gonococcal infection were 9.7 and 1.3%, respectively. Susceptibility of 122 gonococcal isolates to 6 drugs was determined by the disk diffusion method. None of the isolates was susceptible to penicillin or tetracycline. With respect to fluoroquinolones, more than 90% of the isolates were resistant to ciprofloxacin and ofloxacin. No gonococcal isolate with resistance to cefotaxime and ceftriaxone was detected. Among the 122 isolates, 83.6% or 102 isolates were PPNG, and most (79.5%) of these 122 isolates were further identified as PPNG plus tetracycline-resistant N. gonorrhoeae, with only 4.1% being PPNG alone. All of the 102 isolates identified as PPNG contained the blaTEM gene. We then performed a preliminary molecular study and identified, for the first time in Thailand, a PPNG isolate producing beta-lactamase and containing the blaTEM gene which was identical to the beta-lactamase TEM protein of Salmonella enterica identified as TEM-135.