Publication: Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex
Issued Date
2001-08-20
Resource Type
ISSN
01633864
Other identifier(s)
2-s2.0-0034911075
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.64, No.7 (2001), 965-967
Suggested Citation
S. Boonphong, P. Kittakoop, M. Isaka, D. Pittayakhajonwut, M. Tanticharoen, Y. Thebtaranonth Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex. Journal of Natural Products. Vol.64, No.7 (2001), 965-967. doi:10.1021/np000291p Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26453
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Title
Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex
Abstract
Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were isolated from the broth extract of the fungus Xylaria multiplex BCC 1111. Chemical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC50 values of 7 and 2 μg/mL, respectively. Both 1 and 2 were inactive in the screening systems toward the malarial parasite Plasmodium falciparum (at 20 μg/mL) and were not cytotoxic to BC-1 and KB cell lines (at 20 μg/mL).