Publication: Discrepant association of serum C-3 epimer of 25-hydroxyvitamin D versus non-epimeric 25-hydroxyvitamin D with serum lipid levels
Issued Date
2016
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eng
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Mahidol University
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BioMed Central
Bibliographic Citation
Lipids in Health and Disease. Vol. 15, (2016), 157
Suggested Citation
La-or Chailurkit, Wichai Aekplakorn, Kriangsuk Srijaruskul, Boonsong Ongphiphadhanakul Discrepant association of serum C-3 epimer of 25-hydroxyvitamin D versus non-epimeric 25-hydroxyvitamin D with serum lipid levels. Lipids in Health and Disease. Vol. 15, (2016), 157. doi:10.1186/s12944-016-0333-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2720
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Title
Discrepant association of serum C-3 epimer of 25-hydroxyvitamin D versus non-epimeric 25-hydroxyvitamin D with serum lipid levels
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Abstract
Background: Low vitamin D status has been associated with a number of chronic diseases. For dyslipidemia, vitamin
D deficiency has been associated with higher low density lipoprotein-cholesterol (LDL-C) in a number of studies, but
with inconsistent results in clinical trials. The purpose of the present study is to explore the relative importance of
3-epi-25-hydroxyvitamin D (25(OH)D) as compared with the non-epimeric form in relation to serum lipid.
Method: This study used data from 1068 randomly selected volunteers in the Thai 4th National Health Examination
Survey (NHES IV). Serum 25(OH)D2, 25(OH)D3, 3-epi-25(OH)D2 and 3-epi-25(OH)D3 were analyzed by liquid
chromatography–tandem mass spectrometry.
Results: There was no association between serum total 25(OH)D and serum LDL-C. However, circulating
3-epi-25(OH)D3 was negatively related to serum LDL-C (r = −0.077, P <0.05), while no such association was
found for non-epimeric 25(OH)D3 (r =0.030, P = 0.33). On the other hand, both 3-epi-25(OH)D3 (r = 0.175,
P <0.001) and non-epimeric 25(OH)D3 (r = 0.142, P <0.001) were positively related to serum triglyceride (TRIG) levels.
In multiple linear regression models with age, gender, body mass index , urban residence, education,
hypertension and education as covariates, it was found that 3-epi-25(OH)D3 was independently associated with serum
LDL-C (beta = −0.12, P <0.01), while non-epimeric 25(OH)D3 was positively related to LDL-C (beta = 0.13, P = 0.002).
For TRIG, there were positive association with 3-epi-25(OH)D3 (beta = 0.27, P <0.001) and negative association
with non-epimeric 25(OH)D3 (beta = − 0.10, P = 0.011) independent of age, gender, urban resident and
education.
Conclusions: There is a discrepant association of 25(OH)D levels with serum lipids according to 25(OH)D
epimeric forms.